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Every study cited on this site, in one searchable list. Each entry links to its PubMed record or DOI so you can read the original abstract.
30 studies
Piperni E, Nguyen LH, Manghi P, et al. · Cell
In a very large multi-country metagenomic study, carrying Blastocystis was associated with plant-rich diets, lower BMI and better cardiometabolic markers.
Open in PubMed · PMID 38981480Rageh MA, Elmoamaly AA, Zaki WM · Journal of the Egyptian Society of Parasitology
Sensitivity against PCR was 20% for wet mount, 37% for trichrome stain and 71% for culture, all with 100% specificity.
DOI 10.21608/jesp.2024.351359Kumarasamy V, Kuppusamy UR, Pailoor J, Kumar SG · Experimental Parasitology
Exposure to Blastocystis reduced the effectiveness of the chemotherapy drug 5-fluorouracil against colorectal cancer cells in laboratory models.
DOI 10.1016/j.exppara.2023.108564Boutahar M, Belaouni M, Ibrahimi A, Eljaoudi R, Aanniz T, Er-Rami M · Parasite
PCR detected Blastocystis in 67.6% of samples versus 51.4% by culture and 21.0% by direct microscopy; direct microscopy sensitivity was only 31%.
DOI 10.1051/parasite/2023066Deng L, Lee JWJ, Tan KSW · Parasites & Vectors
In patients with diarrhoea, ST7 carriage was linked to lower bacterial diversity and enrichment of Enterobacteriaceae and Escherichia–Shigella.
DOI 10.1186/s13071-022-05435-zGuzmán-Guzmán IP, Nogueda-Torres B, Zaragoza-García O, et al. · Frontiers in Medicine
In rheumatoid arthritis patients, protozoal infection including Blastocystis correlated with higher gut-permeability marker IFABP2 and higher TNF-α.
DOI 10.3389/fmed.2022.846934Stensvold CR, Sørland BA, Berg RPKD, et al. · Microorganisms
Blastocystis carriers had significantly higher microbial diversity and more eubiosis-associated genera such as Prevotella and Faecalibacterium.
Open in PubMed · PMID 35208781El-Zawawy HT, Farag HF, Tolba MM, Abdalsamea HA · Therapeutic Advances in Endocrinology and Metabolism
Hashimoto's patients carrying Blastocystis had higher serum IL-17; after eradication, TSH, anti-TPO antibodies and IL-17 all fell significantly.
Open in PubMed · PMID 32128107Kök M, Çekin Y, Çekin AH, Uyar S, Harmandar F, Şahintürk Y · Turkish Journal of Gastroenterology
Examines Blastocystis as a possible trigger of ulcerative colitis flares, likely acting through altered gut microbiota and mucosal inflammation.
DOI 10.5152/tjg.2018.18498Padukone S, Mandal J, Rajkumari N, Bhat BV, Swaminathan RP, Parija SC · Tropical Parasitology
Against PCR as reference, microscopy reached 36% sensitivity and Jones' medium culture 68%, both with near-perfect specificity — supporting culture plus microscopy where PCR is unavailable.
DOI 10.4103/tp.TP_4_17Mohammad NA, Mastuki MF, Al-Mekhlafi HM, Moktar N, Anuar TS · Iranian Journal of Parasitology
Trichrome staining detected 49% and culture 39% of PCR-positive cases; combining microscopic techniques raised sensitivity to 61%, with false negatives concentrated in subtype 3.
DOI 10.18502/ijpa.v13i1.323Beghini F, Pasolli E, Truong TD, Putignani L, Cacciò SM, Segata N · ISME Journal
Across 1,689 subjects there was no positive association with disease; Blastocystis was less common in colorectal cancer and Crohn's-associated dysbiosis.
DOI 10.1038/ismej.2017.139Nourrisson C, Wawrzyniak I, Cian A, et al. · Parasitology
A secreted, legumain-activated cathepsin B increases permeability of human intestinal cell monolayers; the effect is blocked by the protease inhibitor E-64.
DOI 10.1017/S0031182016001396Nagel R, Traub RJ, Allcock RJN, et al. · Microbiome
IBS patients showed more Firmicutes and fewer Bacteroidetes regardless of Blastocystis status — carriage alone did not explain the phylum-level shift.
DOI 10.1186/s40168-016-0191-0Rajič B, Arapović J, Raguž K, et al. · Journal of Infection in Developing Countries
Case report: metronidazole eradication resolved urticaria and angioedema and thyroid antibodies normalised over four years of follow-up.
Open in PubMed · PMID 26230132Lepczyńska M, Chen W, Dzika E · International Journal of Dermatology
Review concluding that a link between Blastocystis and chronic urticaria is biologically plausible but not yet confirmed, and may be subtype-dependent.
DOI 10.1111/ijd.13064Wu Z, Mirza H, Teo JDW, Tan KSW · BioMed Research International
Subtype 7 — but not subtype 4 — significantly increases apoptosis in human gut cells via caspase 3/9 and disorganises the tight-junction protein ZO-1.
DOI 10.1155/2014/209163Balakrishnan DD, Kumar SG · Parasites & Vectors
Isolates taken from symptomatic patients showed higher caspase-like activity and apoptosis than isolates from asymptomatic carriers.
DOI 10.1186/1756-3305-7-219Wu Z, Mirza H, Tan KSW, et al. · PLoS Neglected Tropical Diseases
Strongly adherent ST7 strains bind intestinal cell junctions, disrupt ZO-1 and occludin and raise permeability; adhesion strength tracks with virulence.
DOI 10.1371/journal.pntd.0002885Nourrisson C, Scanzi J, Pereira B, et al. · PLoS ONE
Blastocystis carriage was associated with reduced protective bacteria (including Bifidobacterium) in the stool of IBS patients compared with controls.
DOI 10.1371/journal.pone.0111868Kumarasamy V, Kuppusamy UR, Samudi C, Kumar S · Parasitology Research
Subtype 3 antigen increased proliferation of HCT116 colorectal cancer cells by roughly a third in vitro, more than the other subtypes tested.
Open in PubMed · PMID 23933809Mirza H, Wu Z, Kidwai F, Tan KSW · Cellular Microbiology
Blastocystis cysteine proteases compromise the epithelial barrier through Rho-kinase signalling (falling resistance, ZO-1 and actin disruption); simvastatin prevents it in vitro.
DOI 10.1111/j.1462-5822.2012.01814.xCase-control study (see DOI record for full author list) · BMC Gastroenterology
Case-control data found Blastocystis significantly more frequent in inflammatory bowel disease overall (OR 2.82) and in ulcerative colitis specifically (OR 2.95).
DOI 10.1186/1471-230X-12-122Zuelfakkar NM, Abdel Hameed DM, Hassanin OM · Clinical and Experimental Dermatology
Blastocystis — especially subtype 3 and the amoeboid form — was significantly more common in patients with urticaria than in controls (P<0.001).
DOI 10.1111/j.1365-2230.2011.04127.xRoberts T, Barratt J, Harkness J, Ellis J, Stark D · American Journal of Tropical Medicine and Hygiene
In 513 stool samples PCR was the most sensitive method (94%) while permanent stained smear microscopy detected only 48% of cases.
DOI 10.4269/ajtmh.2011.10-0447Wu B, Yin J, Texier C, Roussel M, Tan KSW · Journal of Biological Chemistry
A surface-localised legumain protease is required for parasite survival, identifying a virulence-related enzyme and a possible drug target.
DOI 10.1074/jbc.M109.049064Mirza H, Tan KSW · Parasitology Research
Cysteine protease activity differs strongly both between subtypes and between isolates of the same subtype, which helps explain why some carriers are symptomatic and others are not.
Open in PubMed · PMID 18846388Puthia MK, Sio SWS, Lu J, Tan KSW · Infection and Immunity
Even without direct contact, Blastocystis triggers apoptosis, actin rearrangement, lower transepithelial resistance and higher permeability in intestinal epithelial cells.
Open in PubMed · PMID 16790785Puthia MK, Vaithilingam A, Lu J, Tan KSW · Parasitology Research
Blastocystis lysate and conditioned medium cleave secretory IgA through cysteine and aspartic protease activity — a plausible mechanism of mucosal immune evasion.
Open in PubMed · PMID 16151742Lee MG, Rawlins SC, Didier M, DeCeulaer K · Annals of the Rheumatic Diseases
Case report of Blastocystis found in synovial fluid causing infective arthritis in an immunosuppressed rheumatoid arthritis patient.
Open in PubMed · PMID 2322029